Modafinil harmlessness and pharmacodynamics has been studied and proved in several clinical experiments, conducted outside of the USA. Within these studies, patients took 4500 mg of Modafinil orally and didn’t inform about significant clinical side effects (French, J. Aviation, Space and Environment. Medicine. May 1991, 432). Also, the survey didn’t report any statistically or clinic important hemodynamic changes in heart rate or blood pressure level in patients or healthy volunteers, which have been administered trial Modafinil doses.